Grants Awarded to Date

How Your Contributions Have Already Made a Difference

The Catherine Peachey Fund is a 501(c)(3)with an operating overhead of under 5% a year. The funds raised to support our grants have been raised by hundreds of volunteers over many years.

Projects include:  “Just Peachey: Bearing Fruit Cookbook”, Polo with Peachey, Wine Tasting with Peachey at Peace Water Winery, walks/runs, quilt sales, concerts and the sale of “Just Peachey: Cooking up a Cure” cookbooks.

The Amelia Project at the IU Simon Cancer Center

$95,000.00

For 13 years, with Dr. George Sledge as Chair, the Catherine Peachey Fund hosted an annual meeting for scientists and clinicians from across Indiana and guests from around the country. It was at these meetings that many of the projects listed below took form and were then funded by the CPF. It was at the Amelia Project that the first movement toward the Komen Tissue Bank began. The KTB has now gone on to become the only biorepository for normal breast tissue in the world.

2016

Leica CM 1860 Cryostat

$30,000.00

The Lecia CM 1860 Cryostat was purchased for clinical research on behalf of the Breast Cancer Program and the Susan G. Komen Tissue Bank at the I.U. Simon Cancer Center.  BCP and KTB researchers had previously been utilizing a shared Cryostat located miles from their labs on a contractual basis.  The Cryostat is used to section tissues with the purpose of identifying proteins that can serve as biomarkers of disease progression or treatment effects.  The Leica Cryostat will be located centrally for the shared use of the BCP and the KTB for immediate processing of tissue, thus reducing research costs and the time needed to complete projects.

 

2015

The Amelia Project

$75,000.00

The Catherine Peachey fund is pleased to announce a new grant to support the Amelia Project for five years.

Dr. Hari Nakshatri, Dr. Kathy Miller and the Catherine Peachey Fund recently opened the conversation about the value that had been achieved from many years of the Amelia Project. Several important achievements would not have existed without the Catherine Peachey Fund and the IU Simon Cancer Center supporting this annual meeting.

The Amelia Project will include researchers and physicians from all institutions in Indiana doing research in breast cancer. The meeting always pulled its strength from being a multi-institutional day bringing together the best and the brightest. Drs. Rich Zellars (Chair, IUSM Radiation Oncology), Joseph Irudayaraj (Professor and an expert in Nanotechnology and biomedical engineering at Purdue) and Crisyln D’Souza-Schorey (Chair, Department of Biological Sciences, Notre Dame) will be co-chairing the Amelia Project in 2016. This represents outstanding leadership for the new beginning of the Amelia Project.

Dr. Natascia Marino and Dr. Rulla Tamimi

$50,000

The Catherine Peachey Fund is pleased to announce funding for a proposal entitled: Molecular mechanisms behind the association of early-life adiposity and breast cancer risk.

The proposal was submitted by Dr. Natascia Marino from the IU School of Medicine and by Dr. Rulla Tamimi from the Harvard Medical School.

There is accumulating evidence that adolescence and especially the period between menarche and first term pregnancy is an important period for breast cancer susceptibility. Understanding how early life exposures influence breast cancer risk has important implications for understanding breast cancer etiology as well as developing prevention strategies.

This project looks at risk and prevention, uses tissue from the Komen Tissue Bank.

2014

Dr. Hari Nakshatri

$35,500

In 2014, support of the CPF made it possible for us to fund a grant request from Dr. Hari Nakshatri, B.V.Sc.(DVM), Ph.D.,Marian J. Morrison Professor in Breast Cancer Research, Professor of Surgery and of Biochemistry and Molecular Biology. The funding will support work that will allow for the comparative analysis of normal breast epithelial cells from African American and Caucasian women. This grant will allow Dr. Nakshatri to rapidly move forward some of the exciting preliminary data from his laboratory relevant to triple negative breast cancer. The $30,500.00 grant will be matched by funding by the IU Simon Cancer Center.

Dr. Milan Radovich

$50,000

In 2014, the CPF also funded the second year of a two year grant with $50,000 to fund bioinformatics support in sequencing Triple-negative breast cancer for clinical trials. Milan Radovich, PhD, Assistant Professor and Co-Director of the IU Health Precision Genomics Program will be bringing on a very talented PhD student who has extensive experience of next-generation sequencing expertise.

2013

Dr. Milan Radovich

$100,000.00

This grant will provide two years of salary support for a bioinformatician in Dr. Radovich’s laboratory.

Dr. Radovich: “Because of gracious funding from the Catherine Peachey Foundation, we have been able acquire the latest in next-generation sequencing technology, the Ion Proton Sequencer from Life Technologies.

Our primary goal is to use next-generation sequencing technology to help understand three important clinical questions:

1) Can we improve survival of high-risk TNBC patients by incorporating next-generation sequencing into their clinical care; 2) Can we better understand what causes treatment resistance by studying key changes in TNBC cancer genomes; 3) Can we used next-generation sequencing to detect circulating tumor DNA mutations in the blood and use them as biomarkers of treatment response.

Because of the massive amount of data that is produced, and the complexity in analyzing it, highly specialized personnel who are trained in computer science and biotechnology (Bioinformaticians) are needed in order to derive druggable mutations and biological insights.”

2012

Indy’s Super Cure

$25,000.00

The Indianapolis Super Bowl XLVI was an amazing event for Indianapolis and for the Susan G. Komen Tissue Bank at the IU Simon Cancer Center. The Host Committee, under the direction of Allison Melangton, made many lasting contributions to the city and citizens of Indianapolis. The Host Committee created Super Cure as one of its major contributions to the women of Indiana and the world. They raised over $1,000,000.00 for the Komen Tissue Bank and increased the number of donors to the tissue bank by over 800 women in two days of collections. This unique and monumental community effort increased and highlighted the diversity of women through race, ethnicity

Dr. Milan Radovich

$75,000.00

This grant supported the purchase of the Ion Proton Next-Generation Sequencer made by Life Technologies. This new sequencer will greatly advance the capability of the lab to perform research in personalized medicine as well as drug discovery.

2011

Dr. Bryan Schneider

$150,000.00

This grant spanned two years (2011/2012) to support a position in his laboratory for a scientist/technician to help rapidly move forward work utilizing the preliminary data from his laboratory relevant to triple negative breast cancer.

2010

Dr. Hartmut Rohm, Department of Surgery at IU

$50,000.00

This grant supported work in the lab of Dr. Sue Clare on the identification of small molecules against targets identified in the Triple Negative Breast Cancer Transcriptome Sequencing Project.

Dr.Thyagarajan-Sahu

$5,000.00

This grant supported the study of the Anti-Obesity and anti-carcinogentic properties of Ganoderma Luciderm and its component ganodermanontriol GDNT.

Dr. Milan Radovich, Dr. Bryan Schneider, Dr. Sue Clare

$20,000.00

This grant supported decoding the landscape of triple-negative breast cancer compared to micro dissected normal breast tissue using next generation RNA sequencing.

Purdue University International Breast Cancer and Nutrition

$10,000.00

This grant was dispensed over four years for awards to junior scientists for their innovative work in breast cancer research.

Dr. Sue Clare

$3,500.00

This was granted for the purchase of a sophisticated camera for the microscope used to take photos of tissue that has been micro-dissected to produce mRNA for the Virtual Tissue Bank.

2009

Department of Surgery at IU

$14,000.00

This grant supported the salary for the Data Base Manager for the Komen Tissue Bank.

Dr. Sue Clare

$70,000.00

This grant supported research on cores of adipose tissue collected during one of the Komen Tissue Bank collections. The fat-soluble substances stored in the body fat are representative of the cumulative exposure of a woman over her lifetime.

Susan G. Komen Tissue Bank at the IU Simon Cancer Center

$15,000.00

This grant supported the purchase of materials and services not covered under the $1,000,000.00 from Komen to the tissue bank.

Dr. Bryan Schneider

$10,000.00

This grant supported the triple-negative sequencing of the normal tissue being done in his lab by Dr. Radovich.

Cancer Society of St. Joseph County

$32,000.00

Supporting the work of the organization in developing educational programs focusing on nutrition and energy conservation, handling the side effects of treatment, money matters and genetics.

2008

Dr. Anna Maria Storniolo

$5,000.00

This grant funded the research on legal opinions for issues that had not at that time been adjudicated relating to “nonspecific” bio banking for research and also the creation of a “virtual tissue bank.”

Dr. Bryan Schneider

$36,000.00

This grant supported the project and equipment for “association of buccal mucosa vasculary density with genotype and with outcome in the presence of anti-angiogenic therapy.”

2006-2007

Dr. George Sledge and Dr. Steve Williams, Dr. Sunil Badve

$95,000.00

This grant supported the purchase of the Illumina DASL. This piece of equipment will be the cornerstone for doing the necessary laboratory work to begin to mine the data from the “normal tissue” in the biorepository at IU.

Dr. Anna Maria Storniolo

$50,000.00

This grant intended to be given over five years to supplement the salary for the Komen Tissue Bank Administrator.

Dr. Anna Maria Storniolo

$50,000.00

In matching funds with the Broad Ripple Key Club to support the work of The Catherine Peachey Breast Cancer Prevention Program at the IU Simon cancer Center.

2005

Dr. Anna Maria Storniolo

$27,000.00 of $100,000

Pledged for Mary Ellen’s Tissue Bank:  the first biorepository for normal breast tissue that became the precursor to the Susan G. Komen Tissue Bank at the IU Simon Cancer Center.

Dr. Susan Clare

$25,000.00

This was a matching grant with the Department of Surgery for the development of a data base that would serve Mary Ellen’s Tissue Bank for capturing the data in a HIPPA compliant data base and create tracking software capable of inventorying the samples for storage and distribution.

Dr. Phillip Abbosh

$500.00

This travel grant awarded via the Amelia Project to study at IU in conjunction with his Purdue project.

2001-2005

Dr. Anna Maria Storniolo

$1,000,000.00

In 2001, The Catherine Peachey Fund entered into an agreement with Dr. Steve Williams and the IU Breast Program to create a one million dollar endowment to support the Catherine Peachey Breast Cancer Program at IU. Dr. Anna Maria Storniolo has been the Director of this program since its inception until the present. The program has grown and now benefits with the addition of Dr. Lida A. Mina as its Co-Director. This commitment was fully funded by the year 2005, and the program continues today.

2000-2003

Dr. Steve Williams

$150,000.00

During the years 2000-2003, the Catherine Peachey Fund dedicated $150,000.00 of funding to the Vera Bradley Chair held by Dr. Linda Malkas. This commitment continued for three years at $50,000 a year.

Dr. Meei-Huey Jeng

$20,000.00

Dr. Jeng studies how breast cancer becomes resistant to standard hormonal therapies.

1999

Dr. George Sledge

$10,000.00

This grant funded the study of the role of matrix metalloproteinases (MMP) as an inducer of new blood vessel formation.

Dr.Pamela L. Crowell

$20,000.00

This project will characterize two novel breast cancer genes.

Dr. Kathy Miller

$14,669.00

Granted for her project “Breast Cancer Imaging testing Thermoacoustic Computed Tomography: Validation and Physiologic Correlation.”

Dr. George Sledge

$90,000.00

This grant given to support funding for Dr. Shinichi Nozaki, the Doctoral Fellow recruited by Dr. George Sledge to work with him in his laboratory. Dr. Sledge had this to say: “Dr. Nozaki brings to the laboratory a wealth of prior experience with molecular biology techniques, as well as techniques related to angiogenesis.”

Dr.Harikrishna Nakshatri

$19,906.00

This grant supported unique research that is an effort to understand why some breast cancer cells do not respond to chemotherapy and also determine which factors increase breast cells’ sensitivity to treatment.

1998

Dr.Harikrishna Nakshatri

$20,000.00

Dr. Nakshatri’s lab found that a protein called NF-kB was hyperactive in cancer cells that did not respond to chemotherapy. His group identified a compound that reduced NF-kB and made cancer cells respond to chemotherapy. In addition, this compound along with commonly used chemotherapy drugs reduced spreading of breast cancers to other parts of the body in an animal model. A modified form of the compound is now in clinical trial for leukemia and his group hopes to initiate clinical trial in solid tumors in the near future.

Dr. Kenneth Cornetta

$20,000.00

His research project, Gene Therapy for Breast Cancer Using FLT3-Ligand Expressing Vectors, investigates the use of gene therapy to boost the body’s immunity to breast cancer.

1997

Dr. Eric Wiebke

$20,000.00

This study examined of the role of doxycycline in reversing Adriamycin resistance in breast cancer.

Dr. George Sledge, Jr.

$10,000.00

This grant supported the study of the inhibition of breast cancer metastasis by Irsogladine, a novel anti-Angiogenic agent.

Dr.Worta McCaskill-Stevens

$10,000.00

This grant used for supplemental funding for NIHAU Grant: Bone Loss in Premenopausal Women with Breast Cancer Receiving Adjuvant Chemotherapy or Adjuvant Chemohormonal Therapy.

Dr. Michael Gordon, Dr. George Sledge, Jr.

$20,000.00

The Catherine Peachey Fund, Inc. was pleased to participate in procuring instrumentation for an angiogenesis laboratory at the Indiana University Cancer Center.

1996

In 1996, The Catherine Peachey Fund made its first round of grants to researchers at Indiana University. The IU records show that grants totaling $81,568.00 dollars were awarded to: Heereman, Sledge, Cornetta, Crowell and Nozaki. Unfortunately the records do not record the research projects that these grants supported.